Designing Collagen for biomedical needs.

Platform technology enabling cell instruction through engineered bacterial collagens

Designer Collagens are unique in their ability to interact with cells in a manner that directs proper cell response. This is accomplished by identifying specific cues in naturally occurring collagen that direct cellular behavior and inserting it through genetic modification into the Designer Collagen. By giving the cell a single message, you can decrease undesired responses and improve guided regeneration.

Intellectual Property:


Determination of the in vivo degradation mechanism of PEGDA hydrogels. Browning MB, Cereceres S, Luong P, Cosgriff-Hernandez E. . J Biomed Mater Res. 2014. PMID: 24464985.

Drying and Storage Effects on Poly(ethylene glycol) Hydrogel Mechanical Properties and Bioactivity. Luong P, Browning MB, Bixler R, Cosgriff-Hernandez E. J Biomed Mater Res. 2014. PMID: 24123725.

Bioactive hydrogels with enhanced initial and sustained cell interactions. Browning MB, Russell B, Rivera J, Hook M, Cosgriff-Hernandez E. Biomacromolecules. 2013. PMID: 23758437.

Development of a biostable replacement for PEGDA hydrogels. Browning MB, Cosgriff-Hernandez E. Biomacromolecules. 2012. PMID: 22324325.

Multilayer vascular grafts based on collagen-mimetic proteins. Browning MB, Dempsey D, Guiza V, Becerra S, Rivera J, Russell B, Hook M, Clubb F, Miller M, Fossum T, Dong J, Bergeron A, Hahn M, Cosgriff-Hernandez E. Acta Biomaterialia. 2012. PMID: 22142564.

Bioactive Hydrogels Based on Designer Collagens. Cosgriff-Hernandez E, Hahn M, Russell B, Wilems T, Munoz-Pinto D, Browning MB, Rivera J, Hook M. Acta Biomaterialia. 2010. PMID: 20466083.

A Novel α1 Integrin Binding Collagenous Sequence. Seo N, Russell B, Rivera J, Liang X, Xu X, Afshar-Kharghan V, Hook M. The Journal of Biological Chemistry. 2010. PMID: 20675378.